TÚ B1.2

TÚ B1.2 Modeling of cardiovascular system control (prof. Jiří Holčík, PhD)

Research in methodological, mathematical and technical tools for investigation of cardiovascular system activity and control at rest and under various kinds of load. The cardiovascular system and its neural and endocrine control will be based on a model representation using a structural feedback. The proposed research goals are:

  • development of methods for investigation of cardiovascular system by means of linear and nonlinear feedback model of its neural and endocrine control;
  • design of modular HW tools for measuring relevant information about cardiovascular system performance and control;
  • development of the SW tools for computerized determination of the measured signal parameters;

application of the developed tools and procedures for investigation of the cardiovascular system control in anesthesia or under overweighting of pilots during flight, for investigation of drug impact (dobutamine, catecholamine, sedatives, …) to the cardiovascular system performance and/or for studying influence of cardiovascular surgery (e.g. arteriovenous fistula) to the hemodynamics.

Selected outputs of the project during the year 2005 and 2006:

  • Holčík, J. Kozelek, P. Hanák, J. Sedlinská, M.: Mathematical Modeling as a Tool for Recognition of Causes of Disorders in QT/RR Interval Relationship in Equine ECG. Pattern Recognition and Image Analysis. 2005, roč. 15, no. 3, s. 595–598. ISSN 1054–6618.

  • Holčík, J.: System Approach to Cardiovascular System Analysis. Acta Mechanica Slovaca. 2005, roč. 9, no. 2-A, s. 17–22. ISSN 1335–2393.

  • Jirina,M., Jirina.M.: Bounary Effect in Multivariate Data. GESTS Intern.Trans. Copm.Sci.Engng., 2005, vol.11, No.1, s.85–94. ISSN 1738–6438.

  • Jirina,M.,Smrcka,P.: Detection of Repetitive Intervals in the Seismocardiographical Signal. Lékař a technika, 2006, vol.36, č.2, s.319–324, ISSN 0301–5491.

  • Kozelek, P., Holčík, J.: Impact of Variable Autonomous Neural Gain to Cardiovascular System Control. In IFMBE Proceedings World Congress on Medical Physics and Biomedical Engineering 2006 [CD-ROM]. Berlin: Springer-Verlag, 2006, vol. 14, ISBN 3–540–36839

  • Holčík, J., Moudr, J.: Mathematical Model of Seismocardiogram. In IFMBE Proceedings World Congress on Medical Physics and Biomedical Engineering 2006 [CD-ROM]. Berlin: Springer-Verlag, 2006, vol. 14, ISBN 3–540–36839–6.

  • Holčík, J., Moudr, J.: Identification of Cardiovascular System Parameters Using Seismocardiogram. In Proceedings of the 5th European Symposium on Biomedical Engineering [CD-ROM]. Patras: International Federation for Medical & Biological Engineering, 2006

  • Jiřina M., Jiřina M., jr.: Correlation Dimension-Based Classifier, konference IPS, str. 1–13, New York, USA, 5. – 8. 1. 2006, ISBN 86–7466–117–3